Gene information
Official symbol GABRA5
Official full name gamma-aminobutyric acid type A receptor subunit alpha5
Gene type protein-coding gene
Chromosome15q12
Gene familyGamma-aminobutyric acid type A receptor subunits
Resources
Entrez Gene 2558
HGNC HGNC:4079
Ensembl ENSG00000186297
Vega OTTHUMG00000171824
UCSC uc001zbd.3
GO terms: 61 records
GO Description Category LogP Number of genes Detail
GO:0005216 ion channel activity GO Molecular Functions -2.12987867 14 More
GO:0005230 extracellular ligand-gated ion channel activity GO Molecular Functions -1.61683205 4 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007423 sensory organ development GO Biological Processes -8.10586983 29 More
GO:0007605 sensory perception of sound GO Biological Processes -2.56119623 8 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007612 learning GO Biological Processes -4.32260958 18 More
GO:0008306 associative learning GO Biological Processes -3.80327331 12 More
GO:0015267 channel activity GO Molecular Functions -2.12225487 15 More
GO:0015276 ligand-gated ion channel activity GO Molecular Functions -3.44721899 9 More
GO:0015318 inorganic molecular entity transmembrane transporter activity GO Molecular Functions -2.11605072 20 More
GO:0021675 nerve development GO Biological Processes -3.85527067 12 More
GO:0022803 passive transmembrane transporter activity GO Molecular Functions -2.11455525 15 More
GO:0022824 transmitter-gated ion channel activity GO Molecular Functions -1.90014847 4 More
GO:0022834 ligand-gated channel activity GO Molecular Functions -3.44721899 9 More
GO:0022835 transmitter-gated channel activity GO Molecular Functions -1.90014847 4 More
GO:0022836 gated channel activity GO Molecular Functions -2.68852033 13 More
GO:0030425 dendrite GO Cellular Components -4.55233052 48 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042490 mechanoreceptor differentiation GO Biological Processes -3.67373566 10 More
GO:0042596 fear response GO Biological Processes -3.60825621 7 More
GO:0042734 presynaptic membrane GO Cellular Components -4.19875640 10 More
GO:0043025 neuronal cell body GO Cellular Components -9.18558636 52 More
GO:0043523 regulation of neuron apoptotic process GO Biological Processes -14.5388618 39 More
GO:0043524 negative regulation of neuron apoptotic process GO Biological Processes -11.6647584 29 More
GO:0043583 ear development GO Biological Processes -6.67517572 16 More
GO:0044297 cell body GO Cellular Components -11.7206640 62 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0048839 inner ear development GO Biological Processes -5.91339929 14 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0050954 sensory perception of mechanical stimulus GO Biological Processes -4.15913068 20 More
GO:0060078 regulation of postsynaptic membrane potential GO Biological Processes -2.74505261 11 More
GO:0060113 inner ear receptor cell differentiation GO Biological Processes -3.99478704 10 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060384 innervation GO Biological Processes -3.21663541 6 More
GO:0097060 synaptic membrane GO Cellular Components -5.94418548 20 More
GO:0097447 dendritic tree GO Cellular Components -4.82959150 49 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0098936 intrinsic component of postsynaptic membrane GO Cellular Components -4.76116234 10 More
GO:0098948 intrinsic component of postsynaptic specialization membrane GO Cellular Components -4.56568042 8 More
GO:0098960 postsynaptic neurotransmitter receptor activity GO Molecular Functions -2.86473787 9 More
GO:0098982 GABA-ergic synapse GO Cellular Components -3.15908473 6 More
GO:0099055 integral component of postsynaptic membrane GO Cellular Components -4.91964814 10 More
GO:0099056 integral component of presynaptic membrane GO Cellular Components -4.69230219 12 More
GO:0099060 integral component of postsynaptic specialization membrane GO Cellular Components -4.68780123 8 More
GO:0099240 intrinsic component of synaptic membrane GO Cellular Components -5.23284212 12 More
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential GO Molecular Functions -3.0845403 5 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:0099572 postsynaptic specialization GO Cellular Components -2.67743186 13 More
GO:0099634 postsynaptic specialization membrane GO Cellular Components -4.18233935 9 More
GO:0099699 integral component of synaptic membrane GO Cellular Components -4.78109966 11 More
GO:1901215 negative regulation of neuron death GO Biological Processes -19.0527525 45 More
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO Molecular Functions -2.30459914 4 More
GO:1990351 transporter complex GO Cellular Components -2.10211936 13 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa05032 Morphine addiction KEGG Pathway -3.96184640 13 More
hsa05033 Nicotine addiction KEGG Pathway -2.52579963 4 More
Drug-Gene interaction
view
Related drugs: 73 records
Drug name Interaction type Source PMID View
acamprosate calcium ChemblInteractions view
adinazolam potentiator TdgClinicalTrialTEND 61484006320036 view
adipiplon partial agonist TdgClinicalTrialChemblInteractions view
alprazolam allosteric modulatorpositive modulator TdgClinicalTrialChemblInteractionsTEND view
azietomidate DTC 16884293 view
basmisanil allosteric modulator TTD view
bromazepam potentiator TdgClinicalTrialTEND 18384456 view
butabarbital TdgClinicalTrialTEND view
butabarbital sodium positive modulator ChemblInteractions view
butalbital positive modulatorpotentiator TdgClinicalTrialChemblInteractionsTEND 1126444910209232 view
butethal potentiator TdgClinicalTrialTEND 1126444910209232 view
chembl1077391 DTC 19762240 view
chlordiazepoxide positive modulator TdgClinicalTrialChemblInteractionsTEND view
chlordiazepoxide hydrochloride positive modulator ChemblInteractions view
cinolazepam potentiator TdgClinicalTrialTEND 7849137 view
clobazam positive modulator TdgClinicalTrialChemblInteractionsTEND view
clonazepam positive modulator TdgClinicalTrialChemblInteractionsTEND view
clorazepate dipotassium positive modulator ChemblInteractions view
clorazepic acid TdgClinicalTrialTEND view
clotiazepam potentiator TdgClinicalTrialTEND 18855614 view
desflurane positive modulator ChemblInteractions view
diazepam potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 183844561175209015009644 view
enflurane ChemblInteractions view
estazolam potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 6398542889803 view
eszopiclone agonistpositive modulator TdgClinicalTrialChemblInteractions 1897328719942638 view
ethchlorvynol ChemblInteractions view
etomidate DTCChemblInteractions 16884293 view
fludiazepam potentiator TdgClinicalTrialTEND 2857046 view
flumazenil allosteric modulatorantagonist TdgClinicalTrialChemblInteractionsTENDTTD 19907641 view
flunitrazepam allosteric modulatorpotentiator TdgClinicalTrialTEND 20858465171392841701642320638393 view
flurazepam potentiator TdgClinicalTrialTEND 1838445611752090 view
gaboxadol agonist TdgClinicalTrialChemblInteractions view
ganaxolone TdgClinicalTrial view
glutethimide ChemblInteractions view
halazepam potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 67383022867566 view
halothane positive modulator ChemblInteractions view
hexobarbital potentiator TdgClinicalTrialTEND 1126444910209232 view
isoflurane positive modulator ChemblInteractions view
lorazepam positive modulator TdgClinicalTrialChemblInteractionsTEND view
lorediplon positive modulator ChemblInteractions view
mephobarbital potentiator TdgClinicalTrialTEND 211940171126444910209232 view
meprobamate agonist TdgClinicalTrialChemblInteractionsTEND 906732719244096 view
metharbital positive modulatorpotentiator TdgClinicalTrialChemblInteractionsTEND 1126444910209232 view
methohexital sodium positive modulator ChemblInteractions view
methoxyflurane ChemblInteractions view
methyprylon positive modulator ChemblInteractions view
midazolam potentiator TdgClinicalTrialTEND 1838445611752090 view
midazolam hydrochloride positive modulator ChemblInteractions view
nitrazepam potentiator TdgClinicalTrialTEND 1838445611752090 view
ocinaplon allosteric modulator TdgClinicalTrial view
oxazepam positive modulatorpotentiator TdgClinicalTrialChemblInteractionsTEND 1838445611752090 view
pentobarbital potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 1126444910209232 view
pentobarbital sodium positive modulator ChemblInteractions view
pf-06372865 agonist ChemblInteractions view
phenobarbital TdgClinicalTrialTEND view
prazepam potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 7773620 view
primidone positive modulatorpotentiator TdgClinicalTrialChemblInteractionsTEND 1126444910209232 view
propofol positive modulator ChemblInteractions view
quazepam positive modulatorpotentiator TdgClinicalTrialChemblInteractionsTEND 30176902892106 view
remimazolam TdgClinicalTrial view
resequinil inverse agonist ChemblInteractions view
secobarbital potentiator TdgClinicalTrialTEND 1126444910209232 view
secobarbital sodium positive modulator ChemblInteractions view
sevoflurane positive modulator ChemblInteractions view
talbutal potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 1126444910209232 view
temazepam potentiatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 1838445620138190 view
thiamylal sodium positive modulator ChemblInteractions view
thiopental potentiator TdgClinicalTrialTEND 1126444910209232 view
thiopental sodium positive modulator ChemblInteractions view
topiramate ChemblInteractions view
triazolam potentiatorallosteric modulatorpositive modulator TdgClinicalTrialChemblInteractionsTEND 1838445611752090 view
triclofos sodium ChemblInteractions view
zopiclone potentiator TdgClinicalTrialTEND 1897328720303942199426386135616 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cg15665646 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
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